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Full Prescribing Information 1 Indications And Usage To Reduce The Development Of Drug-Resistant Bacteria And Maintain The Effectivness Of Cefazolin For Injection, Usp And Other Antibacterial Drugs. Cefazolin For Injection, Usp Should Be Used Only To Treat Or Prevent Infections That Are Proven Or Strongly Suspected To Be Caused By Susceptible Bacteria. When Culture And Susceptibility Information Are Available, They Should Be Considered In Selecting Or Modifying Antibacterial Therapy. In The Absence Of Such Data, Local Epidemiology And Susceptibility Patterns May Contribute To The Empiric Selection Of Therapy. Cefazolin For Injection, Usp Is Indicated For The Treatment Of The Following Infections When Caused By Susceptible Bacteria. 1.1 Respiratory Tract Infections Respiratory Tract Infections Due To Streptococcus Pneumoniae, Staphylococcus Aureus And Streptococcus Pyogenes. Injectable Benzatine Penicillin Is Considered The Drug Of Choice In Treatment And Prevention Of Streptococcal Infections, Including Prophylaxis Of Rheumatic Fever. Cefazolin Is Effective In The Eradication Of Streptococci From The Nasopharynx; However, Data Establishing The Efficacy Of Cefazolin In The Subsequent Prevention Of Rheumatic Fever Are Not Available. 1.2 Urinary Tract Infections Urinary Tract Infections Due To Escherichia Coli, And Proteus Mirabilis. 1.3 Skin And Skin Structure Infections Skin And Skin Structure Infections Due To S. Aureus, S. Pyogenes, And Streptococcus Agalactiae. 1.4 Biliary Tract Infections Biliary Tract Infections Due To E. Coli, Various Isolates Of Streptococci, P. Mirabilis, And S. Aureus. 1.5 Bone And Joint Infections Bone And Joing Infections Due To S. Aureus . 1.6 Genital Infections Genital Infections Due To E. Coli , And P. Mirabilis . 1.7 Septicemia Septicemia Due To S. Pneumoniae, S. Aureus, P. Mirabilis , And E. Coli . 1.8 Endocarditis Endocarditis Due To S. Aureus And S. Pyogenes. 1.9 Perioperative Prophylaxis The Prophylactic Administration Of Cefazolin Preoperatively, Intraoperatively, And Postoperatively May Reduce The Incidence Of Certain Postoperative Infections In Patients Undergoing Surgical Procedures Which Are Classified As Contaminated Or Potentially Contaminated (E.g., Vaginal Hysterectomy, And Cholecystectomy In High-Risk Patients Such As Those Older Than 70 Years, With Acute Cholecystitis,obstructive Jaundice, Or Common Duct Bile Stones).
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