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Indications And Usage Erythrocin Lactobionate-Iv (Erythromycin Lactobionate For Injection, Usp) Is Indicated In The Treatment Of Infections Caused By Susceptible Strains Of The Designated Organisms In The Diseases Listed Below When Oral Administration Is Not Possible Or When The Severity Of The Infection Requires Immediate High Serum Levels Of Erythromycin. Intravenous Therapy Should Be Replaced By Oral Administration At The Appropriate Time. Upper Respiratory Tract Infections Of Mild To Moderate Degree Caused By Streptococcus Pyogenes (Group A Beta-Hemolytic Streptococci); Streptococcus Pneumoniae (Diplococcus Pneumoniae); Haemophilus Influenzae (When Used Concomitantly With Adequate Doses Of Sulfonamides, Since Many Strains Of H. Influenzae Are Not Susceptible To The Erythromycin Concentrations Ordinarily Achieved). (See Appropriate Sulfonamide Labeling For Prescribing Information). Lower Respiratory Tract Infections Of Mild To Moderate Severity Caused By Streptococcus Pyogenes (Group A Beta-Hemolytic Streptococci); Streptococcus Pneumoniae (Diplococcus Pneumoniae). Respiratory Tract Infections Due To Mycoplasma Pneumoniae . Skin And Skin Structure Infections Of Mild To Moderate Severity Caused By Streptococcus Pyogenes And Staphylococcus Aureus (Resistant Staphylococci May Emerge During Treatment). Diphtheria: As An Adjunct To Antitoxin Infections Due To Corynebacterium Diphtheriae To Prevent Establishment Of Carriers And To Eradicate The Organism In Carriers. Erythrasma: In The Treatment Of Infections Due To Corynebacterium Minutissimum . Acute Pelvic Inflammatory Disease Caused By Neisseria Gonorrhoeae : Erythrocin Lactobionate-Iv (Erythromycin Lactobionate For Injection, Usp) Followed By Erythromycin Stearate Or Erythromycin Base Orally, As An Alternative Drug In Treatment Of Acute Pelvic Inflammatory Disease Caused By N. Gonorrhoeae In Female Patients With A History Of Sensitivity To Penicillin. Before Treatment Of Gonorrhea, Patients Who Are Suspected Of Also Having Syphilis Should Have A Microscopic Examination For T. Pallidum (By Immunofluorescence Or Darkfield) Before Receiving Erythromycin And Monthly Serologic Tests For A Minimum Of 4 Months Thereafter. Legionnaires' Disease Caused By Legionella Pneumophila . Although No Controlled Clinical Efficacy Studies Have Been Conducted, In Vitro And Limited Preliminary Clinical Data Suggest That Erythromycin May Be Effective In Treating Legionnaires' Disease. Prevention Of Initial Attacks Of Rheumatic Fever Penicillin Is Considered By The American Heart Association To Be The Drug Of Choice In The Prevention Of Initial Attacks Of Rheumatic Fever (Treatment Of Group A Beta-Hemolytic Streptococcal Infections Of The Upper Respiratory Tract E.g., Tonsillitis, Or Pharyngitis). 1 Erythromycin Is Indicated For The Treatment Of Penicillin-Allergic Patients. The Therapeutic Dose Should Be Administered For Ten Days. Prevention Of Recurrent Attacks Of Rheumatic Fever Penicillin Or Sulfonamides Are Considered By The American Heart Association To Be The Drugs Of Choice In The Prevention Of Recurrent Attacks Of Rheumatic Fever. In Patients Who Are Allergic To Penicillin And Sulfonamides, Oral Erythromycin Is Recommended By The American Heart Association In The Long-Term Prophylaxis Of Streptococcal Pharyngitis (For The Prevention Of Recurrent Attacks Of Rheumatic Fever). 1 Prevention Of Bacterial Endocarditis Although No Controlled Clinical Efficacy Trials Have Been Conducted, Oral Erythromycin Has Been Recommended By The American Heart Association For Prevention Of Bacterial Endocarditis In Penicillin-Allergic Patients With Prosthetic Cardiac Valves, Most Congenital Cardiac Malformations, Surgically Constructed Systemic Pulmonary Shunts, Rheumatic Or Other Acquired Valvular Dysfunction, Idiopathic Hypertrophic Subaortic Stenosis (Ihss), Previous History Of Bacterial Endocarditis And Mitral Valve Prolapse With Insufficiency When They Undergo Dental Procedures And Surgical Procedures Of The Upper Respiratory Tract. 2 To Reduce The Development Of Drug-Resistant Bacteria And Maintain The Effectiveness Of Erythromycin And Other Antibacterial Drugs, Erythromycin Should Be Used Only To Treat Or Prevent Infections That Are Proven Or Strongly Suspected To Be Caused By Susceptible Bacteria. When Culture And Susceptibility Information Are Available, They Should Be Considered In Selecting Or Modifying Antibacterial Therapy. In The Absence Of Such Data, Local Epidemiology And Susceptibility Patterns May Contribute To The Empiric Selection Of Therapy.
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