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1 Indications And Usage Valproate Sodium Injection, Usp Is An Anti-Epileptic Drug And Is Indicated As An Intravenous Alternative In Patients In Whom Oral Administration Of Valproate Products Is Temporarily Not Feasible In The Following Conditions: Monotherapy And Adjunctive Therapy Of Complex Partial Seizures And Simple And Complex Absence Seizures; Adjunctive Therapy In Patients With Multiple Seizure Types That Include Absence Seizures ( 1 ) 1.1 Epilepsy Valproate Sodium Injection, Usp Is Indicated As An Intravenous Alternative In Patients For Whom Oral Administration Of Valproate Products Is Temporarily Not Feasible In The Following Conditions: Valproate Sodium Injection, Usp Is Indicated As Monotherapy And Adjunctive Therapy In The Treatment Of Patients With Complex Partial Seizures That Occur Either In Isolation Or In Association With Other Types Of Seizures. Valproate Sodium Injection, Usp Is Also Indicated For Use As Sole And Adjunctive Therapy In The Treatment Of Patients With Simple And Complex Absence Seizures, And Adjunctively In Patients With Multiple Seizure Types That Include Absence Seizures. Simple Absence Is Defined As Very Brief Clouding Of The Sensorium Or Loss Of Consciousness Accompanied By Certain Generalized Epileptic Discharges Without Other Detectable Clinical Signs. Complex Absence Is The Term Used When Other Signs Are Also Present. See Warnings And Precautions ( 5.1 ) For Statement Regarding Fatal Hepatic Dysfunction. 1.2 Important Limitations Because Of The Risk To The Fetus Of Decreased Iq, Neural Tube Defects, And Other Major Congenital Malformations, Which May Occur Very Early In Pregnancy, Valproate Should Not Be Administered To A Woman Of Childbearing Potential Unless The Drug Is Essential To The Management Of Her Medical Condition [See Warnings And Precautions ( 5.2 , 5.3 , 5.4 ) , Use In Specific Populations ( 8.1 ) , And Patient Counseling Information (17) ].
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